ABSTRACT BACKGROUND: Acute lymphoblastic leukemia (ALL) is a hematologic malignancy which results from accumulation of lymphoid progenitor cells in the bone marrow and/or extramedullary sites. Philadelphia chromosome (Ph1) positive ALL, a high-risk cytogenetic subset, accounts for 25-30% of adult ALL cases but occurs in less than 5% of children. We aimed with this study to detect BCR-ABL genes fusion, amplification ... إقراء المزيد

Acute lymphoblastic leukemia (ALL) is a clonal malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow (JIANG ET AL., 2010). Cytogenetic abnormalities are independent prognostic variables for predicting the outcome of adult ALL patients. Recent genomic studies have provided a refined genetic map of acute lymphoblastic leukemia (ALL) ... إقراء المزيد

ABSTRACT BACKGROUND. B-cell acute lymphoblastic leukemia (B-ALL) is a malignancy of immature B-cell precursors that proliferate in the bone marrow leading to signs and symptoms of bone marrow failure. Clinical, biological and genetic features are having prognostic significance affecting the outcome of those patients. We aimed with this study to analyze the significance of these factors in affecting patients outcome ... إقراء المزيد

ABSTRACT BACKGROUND. Acute lymphoblastic leukemia (ALL) is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. Philadelphia chromosome (Ph)-positive ALL, a high-risk cytogenetic subset, accounts for 25-30% of adult ALL cases but occurs in less than 5% of children. We aimed with this study to detect Ph ... إقراء المزيد