Abstract
Background. B-cell acute lymphoblastic leukemia (B-ALL) is a malignancy of immature B-cell precursors that proliferate in the bone marrow leading to signs and symptoms of bone marrow failure. Clinical, biological and genetic features are having prognostic significance affecting the outcome of those patients. We aimed with this study to analyze the significance of these factors in affecting patients outcome after treatment with complete or incomplete remission.
Patients and methods. This study was carried out on 39 adults B-cell ALL patients who were attending the hematology oncology clinics. All patients were subjected to; History, clinical examination and Laboratory investigations, which included CBC, PB and BM examination, Immunophenotyping and Fluorescence in situ hybridization.
Results. This study was carried out on 39 adult B-cell ALL patients ( Follow up was done at day 28 of chemotherapy) show: 16 (41%) patients achieved complete remission (CR) ; while 23 (59%) patients showed incomplete remission (IR). Statistical analysis of patients’ outcome with prognostic markers revealed significant association (p<0.05) of CR with TLC <50x109/L (p=0.003) , age <35 yrs (p=0.000) and frequency of t(9;22) with (p=0.05 ).
Conclusion. Age, TLC and t(9;22) are represent the most significant standard prognostic factors in relation to adults B-ALL patients' outcome.