ahmed_ahmed4

Ahmed Roshdi Hamed Ahmed

Professor - Professor of Pathology

Faculty of medicine

Address: Sohag, Naser City.

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Publications Which contain the keyword: Warburg effect

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

2018-10-05 16:22:31 Keywords melanoma, Warburg effect, lact, melanoma, Warburg effect, lactate dehydrogenase, 3-bromopyruvate, paracetamol,
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
3-Bromopyruvate (3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase (LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells (oxidative stress effect) and competes with the LDH substrates pyruvate ... Read more

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

2018-10-10 03:50:59 Keywords 3-bromopyruvate, melanoma, 3-bromopyruvate, melanoma, Warburg effect, lactate dehydrogenase, paracetamol,
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
3-Bromopyruvate (3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase (LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells (oxidative stress effect) and competes with the LDH substrates pyruvate ... Read more

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