Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt



Publications Which contain the keyword: Sarcopenia

Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin
To investigate the role of NLRP3 inflammasome in muscular aging, we evaluated here the morphological and functional markers of sarcopenia in the NLRP3-knockout mice, as well as the beneficial effect of melatonin supplementation. The gastrocnemius muscles of young (3 months), early-aged (12 months), and old-aged (24 months) NLRP3-knockout female mice were examined. Moreover, locomotor activity and apoptosis were assessed. The ... Read more

2018-10-14 19:02:29 Keywords Aging, Apoptosis, autophagosome, melatonin, gastrocnemius, Sarcopenia,
The protective effect of melatonin against age-associated sarcopenia-dependent tubular aggregates formation, lactate depletion and mitochondrial changes
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild type C57BL/6J female mice, were examined by magnetic resonance and microscopy. Locomotor activity, lactate production and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 ... Read more

2018-10-14 09:05:19 Keywords Sarcopenia, Aging, CSA, Type II muscle fibers, Mitochondria,
Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice
The gastrocnemiusmuscle (GM) of young (3months) and aged (12 months) femalewild-type C57/BL6 micewas examined by light and electron microscopy, looking for the presence of structural changes at early stage of the aging process.Morphometrical parameters including body and gastrocnemius weights, number and type ofmuscle fibers, cross section area (CSA), perimeter, and Feret's diameter of single muscle fiber,were measured.Moreover, lengths of the ... Read more

2018-10-14 17:37:04 Keywords Aging, Sarcopenia, Inflammaging, Innate immunity, melatonin,
Aging and Sarcopenia. Role of the innate immunity and melatonin therapy
La inflamación asociada al envejecimiento es un tipo de inflamación crónica, sistémica y asintomática que aparece como resultado de un aumento de la respuesta inmune innata con la edad. Los estímulos que dan lugar a este tipo de inflamación convergen en la activación de las vías moleculares de la inmunidad innata NF-kB y el inflamasoma NLRP3. La inflamación asociada al ... Read more

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