Breast cancer is the most frequent malignant tumor in women worldwide. E-Cadherin is a calcium-dependent epithelial cell adhesion molecule that is expressed at adherens junctions. Its loss may result in a poorly differentiated tumorphenotype. Cells with mutated E-cadherin demonstrate increased motility,altered organization of their actin cytoskeletonandassociated with metastases, thereby providing evidence for its role as an invasion suppressor. Objectives:Assess the prognostic value of E-cadherin expression in invasive duct carcinoma (IDC) of the breastand to evaluate its correlations with other prognostic parameters.Materials and Methods:Immunohistochemical(IHC) E-Cadherin expression was studied in 60 IDC and the results were correlated with the clinico-pathological parameters. Results:E-cadherin was positive in 46/60 (76.7%) of IDC; 15/60 (25%) showed strong membranous staining. A significant inverse correlation was foundbetween E-cadherin expression and number of lymph nodemetastasis. Conclusions:Loss of E-cadherin expressionis a predictive of invasion and metastasis in IDC.Keywords:Breast cancer,invasive duct carcinoma, E-CadherinAbbreviations: IDC: invasive duct carcinoma, IHC: immunohistochemical, PBS:phosphate buffered saline, IHCS:Immunohistochemical scores, PP: percentage of positive cells, staining intensity: SI.Lymphvascular invasion (LVI), Lymph node metastasis (LNM).