Background: When providing high-quality care to patients in a health-care context, therapeutic communication is the most important factor to consider. Therapeutic communication based on information exchange will make patients feel more at ease and secure in their therapy. Aim: to Assess the effect of therapeutic communication educational program for nurses on their nursing care quality. Design: This study was conducted using a quasi-experimental methodology, including pre-, post-, and follow-up program evaluations. Setting: The current study was carried out at Benha University Hospital's General Medical Units. Subjects: The study included a convenient sample of 50 nurses who worked in the previously specified settings. Tools of data collection: Four tools were be used to collect data as follows, (I) personal data form, (II) therapeutic Communication Knowledge test, (III) therapeutic Communication and (IV) quality of nursing care observational checklists. Results: A highly statistically significant positive correlation was discovered among nurses' therapeutic communication knowledge, skills, and quality of nursing care skills score. Conclusion: Implementing a therapeutic communication educational program enhanced nurses' therapeutic communication knowledge, skills and boosting the quality of nursing care. Recommendations: Establish an educational program about documentation, infection control, and patient rights. In addition, the patient's satisfaction with the nursing care process should be assessed on a regular basis. ________________________