The asymmetric unit of the title compound, C48H54O5S4N(C2H5)4+Cl, contains two tetra-tert-butyl[(benzoyl)methoxy]-trihydroxy-tetrathiacalix[4]arene molecules, two tetraethylammonium cations and two chloride anions. The two calixarene molecules in the asymmetric unit each display a cone conformation. There are no significant differences between the two independent molecules. The guest species do not sit within the calixarene ‘buckets’. In the crystal, extensive O—HO, O—HS and O—HCl hydrogen bonds and weak C—HO, C—HS and C— HCl interactions link the thiacalixarene molecules, tetraethylammonium cations and chloride anions, forming a threedimensional network encompassing channels running parallel to the a-axis direction. The structure contains a solventaccessible void of 76 (3) A ˚ 3, but no solvent molecule could reasonably be located. The crystal studied was an inversion twin with a 0.57 (8):0.43 (8) domain ratio.