To increase the potentiality of development and land reclamation activities, the Egyptian government funds the construction of a new desert road in Upper Egypt. This road connects Upper Egypt with the Red Sea Governorate. Surrounding the road is 207,000 acres of land surface which is almost flat and suitable for reclamation. To ensure the sustainability of the proposed development surrounding the road, analyses of the morphometric parameters, infiltration test and the grain size distribution, geoelectrical and hydrogeological investigations were conducted in the area. The results indicated a possibility of flash flood hazards and poor drainage condition for land reclamation activities is expected. The hydrogeological and geoelectrical investigations revealed that the unconfined Quaternary and confined Nubian Sandstone aquifers are the main aquifers in the area. The depths to water in the two aquifers range from 18 to 36 and 80 to 300 m with an average thickness of 40 and 275 m, respectively. The aquifers are made of sands and silt with clay intercalations. The total dissolved solids of water ranges between 1,700 and 5,400 mg/L, whereas the sodium absorption ratio ranges between 7 and 30 meq/L, indicating the suitability of water for irrigating medium- to high-salt-tolerant crops with proper drainage facilities. Thus, water in this area is not suitable for domestic use. Based on hydrogeological equations, the available water for extraction from the aquifers in the area is about 17.195 × 109 m3, and this volume is not feasible to reclaim the whole proposed area for reclamation. Meanwhile, it may be possible to water small farms (not more than 60,000 acres for 50 years). Surface water source should be considered for the sustainability development of the area.