Leser-Trélat syndrome (LTS) is a rare cutaneous paraneoplastic syndrome that barely affects patients with head and
neck cancer. Here we present a case of 58-years old male presented with skin manifestation consistent with a sign of
Leser-Trélat. A close investigation of the patient revealed that he had a recurrent laryngeal squamous cell carcinoma. The
described case is the fifth case of a Leser-Trélat syndrome with squamous cell carcinoma of the larynx and the sixth to
be reported in the head and neck squamous cell carcinoma. Thus sudden development of paraneoplastic dermatoses is
recurrently a forewarning progression of the malignancy.