Abstract Introduction: Postoperative vomiting (POV) after adenotonsillectomy in children is a
common problem with an incidence as high as 40–80%. Only few studies in the literature compared
the effect of different anesthetic techniques concerning postoperative vomiting in children.
Objectives: To compare the effect of granisteron over propofol and sevoflurane in prevention of
POV after adenotonsillectomy in children.
Patients and methods: This cohort, double blind study included 80 children with age between 4
and 12 years, undergoing tonsillectomy ± adenoidectomy, they were divided into 4 equal groups, in
groups (I, II) the induction and maintenance of anesthesia were done by propofol, granisteron was
given 5 min before extubation to group II. In groups (III, IV) induction and maintenance were done
by sevoflurane, granisteron was given 5 min before extubation to group IV.
Results: The incidence of vomiting 24 h after surgery was 30% among all patients, with lower
incidence in groups I and II than groups III and IV. Groups II and IV had the lowest incidence
of postoperative vomiting
Conclusions: On performing adenotonsillectomy in children, the incidence of postoperative
vomiting is lower with (i.v. anesthetics) propofol than (volatile anesthetics) sevoflurane. Use of
granisteron significantly reduces the incidence of postoperative vomiting in children undergoing this
procedure.