Quality of water is a pre-requisite for the success of an irrigation project especially in areas under reclamation. With this view, an effort was made to assess the suitability of groundwater for irrigation purposesin newly reclaimed areas of Sohag Governorate, Egypt. Forty seven samples were collected from groundwater wells tapping the Quaternary aquifer and the locations were recognized using a handheld GPS. The estimation of Ca2+, Mg2+, Na+, K+, CO2-3, HCO1-3, Cl–, SO2-4, EC, TDS and pH was made. Based on that, parameters such as Sodium Adsorption Ratio (SAR), Sodium Percentage (SP), Residual Sodium Carbonate (RSC), Permeability index(PI), Kelley’s Ratio(KI)and Magnesium Hazard (MH) were calculated. The ground water quality information maps of the study area have been prepared using Landsat remote sensing data integrated with GIS spatial interpolation technique. The results showed that 78.72 % and 87.23 % of samples fall under excellent catagory for both SAR and RSC. Regarding to SP more than 95% of samples belonge to medium (46.81%) and bad (48.93%) catagories. In terms of MH and PI 66%, 50% water samples fit for irrigation, whereas regarding KR 90% of samples unsitable for irrigation. More than 70% of water samples in unsafe limits of chloride. It can be inferred from data that except minor discrepancies the groundwater of the study area was categorized as excellent to Good quality and seemed to be suitable for crop production and soil health. The findings of the study can be used for agricultural planning, development and management in the new reclaimed projects in the study area.