Background: Patients with schizophrenia and their families have suffered greatly from negative social attitude toward their illness which results in social discrimination. And this social discrimination leads to many drawbacks in patient's life such as person relationship, education, and work. Objectives: The study aims  to explore the view of non psychiatric medical staff and medical students of Faculty of Medicine, Soahg University towards patients with schizophrenia. Patients and methods: It is a descriptive cross – sectional study conducted in the Faculty of Medicine and its related Hospital of Sohag University. A total sample of 160 non psychiatric  medical staff from resident to professor and 96 6th year  medical students  were enrolled in the study and asked to complete the antistigma questionnaire. The anti-stigma questionnaire was calibrated and structured by the 25 questions divided into three thematic parts, questions were assorted differently, and for each question one of the three offered answers should have been chosen (Yes, No or I don't know).  The questionnaire was self administered. Results: The study showed that all groups had lack of knowledge toward schizophrenia with very high statistically significant difference between four groups ( P value<0.004) .Residents and lecturers represent most poor knowledge followed by students, and then professors. This results in stigmatizing attitude toward patients with schizophrenia & toward their treatment, future rehabilitation and resocialization with statistically significant difference ( P value< 0.019& P value<0.051).  42.2% of females have good knowledge compared to  33.9% of the  males and the difference is significant(P value < 0.024). but there is no significant difference between males and females in their stigmatizing attitude. Conclusion: Insufficient knowledge leads to stigmatizing attitudes among non psychiatric medical staff which could lead to decrease quality of life and seeking medical advice among schizophrenic patients.