Tidal volume delivery and endotracheal tube leak during cardiopulmonary resuscitation in intubated newborn piglets with hypoxic cardiac arrest exposed to different modes of ventilatory support

There are few data available on the interaction of inflations, chest compressions (CC), and delivery of tidal volumes in newborn infants undergoing resuscitation in the presence of endotracheal tube (ET) leaks.

To determine the effects of different respiratory support strategies along with CC on changes in tidal volume and ET leaks in hypoxic newborn piglets with cardiac arrest.

Asphyxiated newborn piglets, intubated with weight-adapted uncuffed ET, were randomized into three groups and resuscitated according to ILCOR 2010 guidelines:(1) T-piece resuscitator (TPR) group= peak inspiratory pressure (PIP)/positive end-expiratory pressure (PEEP) 25/5 cm H 2 O, rate 30/min, inflations interposed between CC (3: 1 ratio);(2) self-inflating bag (SIB) group= PIP 25 cm H 2 O without PEEP, rate 30/min, inflations interposed between CC (3: 1 ratio), and (3) ventilator group= PIP/PEEP of …