Information and communication technologies (ICTs) increasingly promoted as a key solution for comprehensive development, poverty eradication and empowerment of disadvantaged groups, such as women and minorities in the world. ICT-based initiatives have been hailed as “potential goldmines” for women’s empowerment. However, research and experience shows that to be successful, the initiatives must balance the need to overcome structural barriers to women’s advancement with sensitivity to the limited space within which many women in the world navigate. In this paper, we comparatively analyzed the ICT- based initiatives in terms of gender empowerment, drawing upon two empowerment initiatives from two developing countries (India and Egypt) as case studies to compare the gender empowerment status through such ICT- based initiatives in both the two countries. Some of the findings have been found such as: 1) there are certain practices has been followed to benefit the women as well as men in the studied initiatives in the various topics of the modern live (i.e. Agriculture, Health, Education, Social welfare and e-Governance), 2)the women are equally empowered to access such applied practices, 3) the ICT- based support is an effective factor against the gender divide traditional world and 4)Women societal involvement has to be targeted while forming a smart empowerment strategy 3) The ICT- based training is one of the most required activity towards gender empowerment. We anticipate that the insights outcomes from this study will be useful for purposes of effective program development and gender empowerment strategy designers of both the two countries.