Six sweet melon (Cucumis melo var. aegyptiacus) inbred lines, ‘Ana-3’ (L1), ‘Esm-4’ (L2), ‘War-4’ (L3), ‘Fal-5’ (L4), ‘Mas-4’ (L5) and ‘Kha-4’ (L6), were utilized in line × tester top crosses with three muskmelon (Cucumis melo var. reticulatus) inbred lines ‘Kur-2’ (T1), ‘Gw-4’ (T2) and ‘Hira-2’ (T3), resulting in 18 hybrids (F1) during the fall season (August-November) of 2008. The eighteen nested genotypes were evaluated in comparison with their respective parents during the hot summer season (JuneSeptember) of 2009, in newly reclaimed sandy soil in open fields. Growth performance at flowering stage, number of days to the first female flower (D1ST FF), earliness (EY), total yield (TY) and fruit quality characters were determined. Also, field tolerance to gummy stem blight (GSBT) during fruit maturity period was recorded. All genotypes (parents and hybrids) differed significantly from each other for all investigated traits. In terms of general combining ability (SCA), the three lines L1, L2 and L3 and two testers T1 and T3 may be considered as good combining parents for simultaneous improvement of most of the yield and fruit quality traits. For both yield and fruit quality traits, the crosses L3×T2, L4×T1 and L5×T3 exhibited significant SCA effects for yield traits and total soluble solids (TSS %), L2×T1 for both yield traits and fruit shape index (FSI) and L2×T2 for main stem length (MSL; cm), average fruit weight (AFW; g) and flesh thickness (FTh; cm). MSL, TY, FTh, net flesh percentage and GSBT showed positive significant average heterobeltiosis, while number of branches, number of leaves, EY, AFW, TSS and FSI manifested negative significant average heterobeltiosis for several crosses