Purpose. To evaluate the efficacy and safety of air bubble technique for vitrectomy in aphakia. Study Design. Prospective

interventional uncontrolled case series. Methods. This study included 53 eyes of 53 patients who are phakic and indicated

for phacovitrectomy (7 eyes, group 1), aphakic and indicated for vitrectomy (22 eyes, group 2), or underwent unplanned

vitrectomy for immediate management of a phacoemulsification surgery complicated by rupture posterior capsule with dropped

nucleus, fragments, or IOL (24 eyes, group 3). Cases with complicated vitreoretinal pathology were not included in this study.

All vitrectomy surgeries were conducted by the air bubble technique in the anterior chamber. Main outcomes included

anatomical success, visual acuity, and intraoperative and postoperative complications. Results. The surgical success was achieved

in 50 eyes (94.3%). Conversion to BIOM viewing system was needed in the retinal detachment cases of groups 1 and 2. The

mean overall LogMAR visual acuity was significantly improved from 1.29 ± 0.58 preoperatively to 0.56 ± 0.19 at the final visit,

6 months postoperatively (P < 0 001). Conclusion. The air bubble technique as visualization method for vitrectomy in

aphakia is an effective and cheap technique for immediate management of complications of phacoemulsification surgery.

This trial is registered with Pan African Clinical Trial Registry PACTR201709002466296