Abstract: Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has little side effects and isrelatively cheap and locally available. This study investigated the antihyperlipidemic effect of eugenol in tritonwr1339 induced hyperlipidemia in rats. The hyperlipidemic rats were randomized into six groups and administered groups,group 1 saline (0.9 NaCl), group 2 sesame oil, group 3 eugenol (250mg/kg), group 4atorvastatin (40 mg/kg), group 5atorvastatin and eugenol and group 6 hyperlipidemic pretreated with eugenol. The animals were treated orally once daily for seven days. The results clearlydemonstrated that eugenolas well as atorvastatin produced highly significant decline in lipid profile. Combination of eugenol and atorvastatin showed highly significant reduction in lipid profile. Eugenol revealed highly significant reduction in lipid profile when administered seven days before hyperlipidemia induction. Administration of eugenol showed highly significant increase in SOD level in liver while significant elevation in kidney tissue. Eugenol produced highly significant elevation in CAT levelin liver and kidney tissues. Atorvastatin showed no significant change in SOD level while significant elevation on CAT level in liver and highly significant increase in kidney tissue.Combination of eugenol and atorvastatin revealed highly significant increase in SOD and CAT in both liver and kidney tissues. Administration of eugenol one week before hyperlipidemia induction showed no significant change in SOD in liver and kidney tissues and CAT in liver but there was high significant increase in the activity of CAT in kidney. These results indicate that combination of atorvastatin and eugenol improves lipid profile and the activities of SOD and CAT in both liver and kidney tissues. To overcome hyperlipidemia problems and its side effects, eugenol might provide a useful source of new oral hypolipidemic and antioxidant compound for the development of pharmaceuticals entities or as dietary adjunct to existing therapies.