Background
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
characterized by widespread epidermal necrosis and mucosal involvement secondary
to keratinocyte apoptosis induced mostly by drugs and associated with high mortality.
Objective
To examine the prevalence, etiology, clinical presentations, and outcome of SJS/TEN in
patients admitted in the Department of Dermatology, Venereology, and Andrology,
Faculty of Medicine, Sohag University, Sohag, Egypt.
Patients and methods
This observational study included all patients with SJS/TEN admitted in the
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag
University, Sohag, Egypt, between September 2013 and September 2014. All patients
with SJS/TEN were subjected to complete medical history and examinations to
evaluate the extent of skin and mucous membrane involvement, complications, and
other system affections. They also underwent complete laboratory investigations. The
severity-of-illness score for toxic epidermal necrolysis was used to evaluate all patients
within the first 24 h of admission.
Results
Of the 500 patients admitted, 21 (4.2%) were diagnosed with SJS/TEN (six men and
15 women; mean age 30.4 years). Fourteen patients were diagnosed with SJS
(n = 14; 66.7%), three with SJS/TEN overlap (n = 3; 14.3%), and four with TEN (n = 4;
19%). Nineteen patients (90.5%) had a history of drug intake. The most common
causative drugs were carbamazepine (33.3%) and antibiotics + NSAIDs (28.57Background
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
characterized by widespread epidermal necrosis and mucosal involvement secondary
to keratinocyte apoptosis induced mostly by drugs and associated with high mortality.
Objective
To examine the prevalence, etiology, clinical presentations, and outcome of SJS/TEN in
patients admitted in the Department of Dermatology, Venereology, and Andrology,
Faculty of Medicine, Sohag University, Sohag, Egypt.
Patients and methods
This observational study included all patients with SJS/TEN admitted in the
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag
University, Sohag, Egypt, between September 2013 and September 2014. All patients
with SJS/TEN were subjected to complete medical history and examinations to
evaluate the extent of skin and mucous membrane involvement, complications, and
other system affections. They also underwent complete laboratory investigations. The
severity-of-illness score for toxic epidermal necrolysis was used to evaluate all patients
within the first 24 h of admission.
Results
Of the 500 patients admitted, 21 (4.2%) were diagnosed with SJS/TEN (six men and
15 women; mean age 30.4 years). Fourteen patients were diagnosed with SJS
(n = 14; 66.7%), three with SJS/TEN overlap (n = 3; 14.3%), and four with TEN (n = 4;
19%). Nineteen patients (90.5%) had a history of drug intake. The most common
causative drugs were carbamazepine (33.3%) and antibiotics + NSAIDs (28.57Background
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
characterized by widespread epidermal necrosis and mucosal involvement secondary
to keratinocyte apoptosis induced mostly by drugs and associated with high mortality.
Objective
To examine the prevalence, etiology, clinical presentations, and outcome of SJS/TEN in
patients admitted in the Department of Dermatology, Venereology, and Andrology,
Faculty of Medicine, Sohag University, Sohag, Egypt.
Patients and methods
This observational study included all patients with SJS/TEN admitted in the
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag
University, Sohag, Egypt, between September 2013 and September 2014. All patients
with SJS/TEN were subjected to complete medical history and examinations to
evaluate the extent of skin and mucous membrane involvement, complications, and
other system affections. They also underwent complete laboratory investigations. The
severity-of-illness score for toxic epidermal necrolysis was used to evaluate all patients
within the first 24 h of admission.
Results
Of the 500 patients admitted, 21 (4.2%) were diagnosed with SJS/TEN (six men and
15 women; mean age 30.4 years). Fourteen patients were diagnosed with SJS
(n = 14; 66.7%), three with SJS/TEN overlap (n = 3; 14.3%), and four with TEN (n = 4;
19%). Nineteen patients (90.5%) had a history of drug intake. The most common
causative drugs were carbamazepine (33.3%) and antibiotics + NSAIDs (28.57Background
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
characterized by widespread epidermal necrosis and mucosal involvement secondary
to keratinocyte apoptosis induced mostly by drugs and associated with high mortality.
Objective
To examine the prevalence, etiology, clinical presentations, and outcome of SJS/TEN in
patients admitted in the Department of Dermatology, Venereology, and Andrology,
Faculty of Medicine, Sohag University, Sohag, Egypt.
Patients and methods
This observational study included all patients with SJS/TEN admitted in the
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag
University, Sohag, Egypt, between September 2013 and September 2014. All patients
with SJS/TEN were subjected to complete medical history and examinations to
evaluate the extent of skin and mucous membrane involvement, complications, and
other system affections. They also underwent complete laboratory investigations. The
severity-of-illness score for toxic epidermal necrolysis was used to evaluate all patients
within the first 24 h of admission.
Results
Of the 500 patients admitted, 21 (4.2%) were diagnosed with SJS/TEN (six men and
15 women; mean age 30.4 years). Fourteen patients were diagnosed with SJS
(n = 14; 66.7%), three with SJS/TEN overlap (n = 3; 14.3%), and four with TEN (n = 4;
19%). Nineteen patients (90.5%) had a history of drug intake. The most common
causative drugs were carbamazepine (33.3%) and antibiotics + NSAIDs (28.57Background
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
characterized by widespread epidermal necrosis and mucosal involvement secondary
to keratinocyte apoptosis induced mostly by drugs and associated with high mortality.
Objective
To examine the prevalence, etiology, clinical presentations, and outcome of SJS/TEN in
patients admitted in the Department of Dermatology, Venereology, and Andrology,
Faculty of Medicine, Sohag University, Sohag, Egypt.
Patients and methods
This observational study included all patients with SJS/TEN admitted in the
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag
University, Sohag, Egypt, between September 2013 and September 2014. All patients
with SJS/TEN were subjected to complete medical history and examinations to
evaluate the extent of skin and mucous membrane involvement, complications, and
other system affections. They also underwent complete laboratory investigations. The
severity-of-illness score for toxic epidermal necrolysis was used to evaluate all patients
within the first 24 h of admission.
Results
Of the 500 patients admitted, 21 (4.2%) were diagnosed with SJS/TEN (six men and
15 women; mean age 30.4 years). Fourteen patients were diagnosed with SJS
(n = 14; 66.7%), three with SJS/TEN overlap (n = 3; 14.3%), and four with TEN (n = 4;
19%). Nineteen patients (90.5%) had a history of drug intake. The most common
causative drugs were carbamazepine (33.3%) and antibiotics + NSAIDs (28.57