REPAIR
Definitions
Regeneration
Repair by fibrosis, Healing
Organization
CELLULAR PROLIFERATION
The cell cycle
Classification of cells according to the proliferative potential
Labile cells
Characters
Sites
Stable cells
Characters
Sites
Permanent cells
Characters
Sites
Stem Cells
Definition
Classifications
Properties
Self-renewal
Potency
Totipotency
Pluripotency
- Embryonic stem cells
Multipotent progenitor cells
Oligopotency
Unipotent cell
Adult stem cells
Fetal stem cells
Amniotic stem cells
Induced pluripotent stem cells
CONTROL MECHANISM IN REPAIR
Growth factors: types and effects
Mechanisms of action
Extracellular matrix (ECM)
Synthesis and degradation of ECM
Forms of ECM
Interstitial matrix
Basement membrane
Collagen
Types and distribution
Components of ECM
Role of ECM
Removal of chemical factors inhibiting mitosis
Removal of contact inhibition
Cell and tissue regeneration
Repair by connective tissue
Angiogenesis
Mechanism of angiogenesis
Steps of angiogenesis
Growth factors involved in angiogenesis
Migration of fibroblasts & fibroplasia
Fibroplasia (Femrogenesis )
Migration of fibroblasts & fibroplasia
ECM deposition (scar formation)
ECM and tissue remodeling
Wound healing
This process is classically divided into phases
Hemostasis (blood clotting)
Inflammation
Proliferation (growth of new tissue)
Maturation (remodeling)
Timing and re-epithelialization
Granulation tissue
Collagen deposition
Epithelialization
Mechanism
Contraction
Mechanism
Maturation and Remodeling
Cutaneous wound healing
Primary union of wounds (healing by first intention)
The sequence of events in primary union
Initial hemorrhage
Morphology of granulation tissue
Secondary union of wounds (healing by second intention)
Differences between primary and secondary union of wounds
Wound strength
Factors affecting wound healing
Complications of wound healing
Repair of bone fracture
Reactive phase
Reparative phase
Remodelling phase
Failure of bony union
Complications of fracture healing
Neuroregeneration
Peripheral nervous system regeneration
Repair in Central nervous system
