REPAIR
Definition
Differences between “regeneration” and “healing”
Factors affecting repair
Local factors
General factors
Types of Repair
Regeneration
Healing or fibrosis
Regeneration
Definition
Types of cells
Continuously dividing (labile) cells
Quiescent “stable cells”
Permanent cells
Stem Cells
Definition
Classifications
Properties
Self-renewal
Potency
Totipotency
Pluripotency
Embryonic stem cells
Multipotent progenitor cells
Oligopotency
Unipotent cell
Adult stem cells
Fetal stem cells
Amniotic stem cells
Induced pluripotent stem cells
Regeneration of skin
Regeneration of liver cells
Repair of bone fracture
Failure of bony union
Repair in nervous system
Central nervous system
Peripheral nerves
Healing by fibrosis
Mechanism
Angiogenesis
Fibrogenesis
Healing of wounds
Primary union of wounds (healing by first intention)
Secondary union of wounds (healing by second intention)
Complications of wound healing, keloid, contraction, implantation (epidermoid) cyst and sqamous cell carcinoma
Healing of serofibrinous inflammation
Control mechanisms in repair
Growth factors
Platelet derived growth factor (PDGF
Epidermal growth factor (EGF
Macrophage derived growth factor (MDGF
Fibroblast growth factor (FGF
Removal of chemical factors inhibiting mitosis
Removal of contact inhibition
