عبدالرحيم محمد احمد محمود

مدرس -

كلية العلوم

العنوان: جامعة سوهاج - كلية العلوم - قسم الكيمياء


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2016 | الكلمات المفتاحية phase transfer catalysis,
Synthesis of Novel Fused Heterocycles Based on 6-Amino-4-phenyl-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile
Under phase transfer catalysis conditions, 6‐amino‐4‐phenyl‐2‐thioxo‐1,2‐dihydropyridine‐3,5‐dicarbonitrile (1) was allowed to react with halo compounds, acrylonitrile, chloroacetyl chloride, ethyl cyanoacetate, formamide, triethylorthoformate, or formic acid to give new derivatives of fused pyridines 2–22, respectively. Acetylation of compound 1 using acetic anhydride afforded product 23, which in turn underwent intramolecular cyclization in pyridine to give the corresponding pyrido[2,3‐_d_]pyrimidine 24. إقراء المزيد

2015 | الكلمات المفتاحية PASS INET, fused pyridine, pyrrazole, Pyrimidine, pyrrole, pyridine, phase transfer catalysis,
Synthesis  of  Some  New F used  P yridines  and  Prediction  their  Biological Activity via PASS INET
A new series of fused heterocyclic compounds containing pyridine moieties were prepared via the reaction of 2-amino-6-(methylthio)-4-phenylpyridine-3,5-dicarbonitrile with some halo reagents, active methylenes, acetic anhydride, phenylisothiocyanate, hydrazine hydrate or thioacetamide. Accompanied with Predictions of the activity spectra of some selected compounds using PASS INET.at Pa > 70%, showing high probability of Atherosclerosis treatment, Antineoplastic, DNA intercalator, Protein kinase inhibitor and ... إقراء المزيد

Synthesis and Antimicrobial Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones
A series of substituted -nitrotetrazole-5-carbaldehyde hydrazones were synthesized and tested for antimicrobial activity with respect to _Staphylococcus aureus_, _Streptococcus pneumoniae_, _E. coli_, _P. aeruginosa_, and _Micrococcus_. The minimum inhibitory concentrations were determined. إقراء المزيد

2014 | الكلمات المفتاحية Synthesis, nitrotetrazole-5-carbaldehyde, antifungal activity,
Synthesis and Antifungal Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones
A series of nitrotetrazole-5-carbaldehyde hydrazones was synthesized and their antifungal activity against _Candida albicans_, _Microsporum canis_, and _Trichophyton rubrum_ was assessed. إقراء المزيد

2014 | الكلمات المفتاحية Cyanogen Bromide, Dinitro, Silver Salt, White Crystal, Oxadiazole,
Synthesis of 2-(2-methyltetrazol-5-yl)-2,2-dinitroacetonitrile and its reaction with substituted nitrile N-oxides
A procedure of synthesis of 2-(2-methyltetrazol-5-yl)-2,2-dinitroacetonitrile has been developed and its reaction with substituted nitrile _N_-oxides has been investigated, proceeding by the mechanism of 1,3-dipolar cycloaddition and affording 2-methyl-5-[(1,2,4-oxadiazol-5-yl)(dinitro)methyl]-2_H_-tetrazoles. The latter react with KOH in ethanol forming the potassium salt of 2-methyltetrazol-5-yldinitromethane and substituted 5-hydroxy-1,2,4-oxadiazoles. إقراء المزيد

2013 | الكلمات المفتاحية Azole, Isoxazole, Diazo Compound, Anhydrous Diethyl Ether, Dinitromethyl,
Synthesis of 5-(chlorodinitromethyl)-2-methyl-2H-tetrazole and its reaction with diazoalkanes
It is known that 5-dinitromethyl-2-methyl-2H-tetrazole (I) reacts with diazomethane to give isomeric methyl (2-methyltetrazol-5-yl)nitromethanenitronates and (1,3-dimethyl-1H-tetrazol-5-yl)dinitromethylide [1]. With a view to study how the nature of substituted 5-dinitromethyltetrazoles affects the direction of their reactions with diazo compounds, we have synthesized an analog of tetrazole (I), 5-(chlorodinitromethyl)-2- methyl-2H-tetrazole (II), and examined its reactions with diazomethane (III) and diazoethane (IV). Tetrazole (II) ... إقراء المزيد

Synthesis of 2-(2-methyltetrazol-5-yl)-2,2-dinitroacetonitrile. Reaction of the nitrile group with diazomethane
The reaction of the silver salt of (2-methyltetrazol-5-yl)dinitromethane with cyanogen bromide led to the formation of 2-(2-methyltetrazol-5-yl)-2,2-dinitroacetonitrile. The nitrile group of the latter was capable of entering into 1,3-dipolar cycloaddition with diazomethane, giving a mixture of isomeric 2-methyl-5-[(_N_-methyl-1,2,3-triazol-4-yl)dinitromethyl]tetrazoles that were separated by column chromatography. Upon treatment with an alcohol solution of potassium hydroxide, denitration of the cycloaddition products occurred and ... إقراء المزيد

Nitration of styrenes using 2-methyl-5-trinitromethyltetrazole
2-methyl-5-trinitromethyltetrazole (1) reacts with the styrenes 2A-D as a nitrating agent. The reaction of tetrazole 1 with the ethenes 2A-D in a neutral medium results in the denitration of compound 1 to give the α-nitro ketones 3A-C (from the alkenes 2A-C) or the 1-methyl-2-nitro-1-phenyl-1-ethanol 3D (from alkene 2D). In addition, the degradation products of compound 1 (the nitromethanone oxime 4 ... إقراء المزيد

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