eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

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Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast

2020 | Keywords VCAM-1, Breast Cancer,
Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast
Background and Aim: VCAM-1 (CD106) expressed mainly on activated endothelial cells in response to pro-inflammatory cytokines. Recent evidences suggest that it is closely correlated with tumor formation, angiogenesis and cancer progression. The aim of the current study was to evaluate expression status of VCAM-1 in mammary invasive ductal carcinoma (IDC), and to correlate its expression with some known clinicopathological data. ... Read more

Immunohistochemical expression of Nestin as Cancer Stem Cell Marker in gliomas

2019 | Keywords Nestin, gliomas, stem cell,
Immunohistochemical expression of Nestin as Cancer Stem Cell Marker in gliomas
Background: Gliomas represent the most frequent primary tumors of central nervous system (CNS), contributing to more than half of the incidence of brain tumors. Cancer stem cell markers (CSC) identify a group of patients at high risk for progression. Nestin is an intermediate filament (IF) protein was first described as a neural stem cell/progenitor cell marker. Nestin-positive neuroepithelial stem cells ... Read more

2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury

2019 | Keywords hypertension, Angiotensin, Cardiovascular Remodeling, Renal injury, Methoxyestradiol,
2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury
Estradiol may antagonize the adverse cardiovascular effects of angiotensin II (Ang II). We investigated the effects of 2-methoxyestradiol (2-ME), a nonestrogenic estradiol metabolite, on Ang II-induced cardiovascular and renal injury in male rats. First, we determined the effects of 2-ME on Ang II-induced acute changes in blood pressure, renal hemodynamics, and excretory function. Next, we investigated the effects of 2-ME ... Read more

A Comparative Study of Conventional Cytology and Cellblock Method in Diagnosis of Pleural Effusion and their Correlation with Clinicopathological and Radiological Diagnosis

2019 | Keywords Cytology, pleural effusion,
A Comparative Study of Conventional Cytology and Cellblock Method in Diagnosis of Pleural Effusion and their Correlation with Clinicopathological and Radiological Diagnosis
Background: Cytological Smear (CS) is extremely useful in patients with pleural effusions especially when malignancy is suspected. Cellblock (CB) technique is another method for examination of pleural fluid. In this study we aimed to compare the diagnostic yields of CS and CB technique and the combi-nation of both, regardless of the etiology of Pleural Effusion (PE), and to compare their ... Read more

Protective Effect of vitamin C against Aspartame Toxicity to the Testes: A review article

2019 | Keywords Vitamin C, Aspartame, testes,
Protective Effect of vitamin C against Aspartame Toxicity to the Testes: A review article
Background: Aspartame is one of the most widely used artificial sweeteners.Aspartame has been shown to induce oxidative stress and lipid peroxidation; most serious effects result from chronic exposure due to these effects. Also it shows organ and species toxicity with relation to the liver, kidney, brain, testis and other organs.The aim of this study is to spotlight on aspartame hazards ... Read more

Aspartame: Basic Information for Toxicologists

2019 | Keywords Aspartame, Toxicologists,
Aspartame: Basic Information for Toxicologists
Background: Aspartame is one of the most widely used artificial sweeteners in over 90 countries worldwide in over 6000 products, including carbonated and powdered soft drinks, hot chocolate, chewing gum, candy, desserts, yogurt, and tabletop sweeteners, as well as some pharmaceutical products like vitamins and sugar-free cough drops. Aspartame has been shown to induce oxidative stress and lipid peroxidation; most ... Read more

Immunohistochemical Expression of Cancer Stem Cell marker Aldehyde dehydrogenase 1B1 (ALDH1B1) in Colorectal Carcinoma

2018 | Keywords stem cell, ALDH1B1, colorectal,
Immunohistochemical Expression of Cancer Stem Cell marker Aldehyde dehydrogenase 1B1 (ALDH1B1) in Colorectal Carcinoma
Background: Colorectal cancer (CRC) is the third most common cause of cancer-related death in the US. One out of four patients presenting with conventionally staged node negative disease (AJCC Stage I and II), and over 50% of patients with Stage III disease will develop local recurrence and/ or metastases. Across all stages, approximately 30% of patients will develop distant metastases. ... Read more

Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction

2018 | Keywords Preserved Ejection Fraction, Heart Failure, Rat Model, Renal Disease, cardiovascular, Captopril,
Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction
نبذة مختصرة Heart failure with preserved ejection fraction (HFpEF), a prevalent form of heart failure, is frequently accompanied by the metabolic syndrome and kidney disease. Because current treatment options of HFpEF are limited, evaluation of therapies in experimental models of HFpEF with the metabolic syndrome and kidney disease is needed. In this study, we evaluated the effects of captopril, furosemide, ... Read more

The Value of CD34 Expression in Squamous Cell Carcinoma and Urothelial Carcinoma of the Urinary Bladder

2018 | Keywords Urothelial carcioma, CD34, SCC,
The Value of CD34 Expression in Squamous Cell Carcinoma and Urothelial Carcinoma of the Urinary Bladder
Background: Angiogenesis is important in the development of solid tumors. A variety of markers for identification of microvessels in histological sections are available, cluster of differentiation 34 (CD34) is one of the most commonly used factors. Aims: To evaluate the expression of CD34 in invasive squamous cell carcinoma (SCC) and urothelial carcinoma (UC) of the urinary bladder and correlation of ... Read more

HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis

2017 | Keywords Endometriosis, Endometrial Tissues, HOXB4,
HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis
Endometriosis is a common disease characterized by the presence of ectopic endometrial tissue. Although the pathogenesis of endometriosis remains unclear, several factors have been implicated, including the dysregulation of homeobox (HOX) genes. Our objective was to investigate the localization and immunoreactivity of HOXB4 in endometrial tissues from women with or without endometriosis. We studied samples of eutopic endometrium (EE), endometriomas ... Read more