mai.h.elnaggar

Mai El-Naggar

Lecturer -

Faculty of Pharmacy

Address: Pharmacognosy Department- Faculty of Pharmacy- Sohag University

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Antimicrobial and antiquorum-sensing activity of Ricinus communis extracts and ricinine derivatives

2018-09-24 03:35:43 | Keywords ricinine alkaloid, antiquorum-sensing, Ricinus communis L, Antimicrobial,
Antimicrobial and antiquorum-sensing activity of Ricinus communis extracts and ricinine derivatives
Ricinine (1), a known major alkaloid in Ricinus communis plant, was used as a starting compound for the synthesis of six ricinine derivatives; two new and four known compounds. The new derivatives; 3-amino-5-methyl-1H-pyrazolo[4,3-c]pyridin-4(5H)-one (2), and 3-amino-5-methyl-1-(phenylsulfonyl)-1H-pyrazolo[4,3-c]pyridin-4(5H)-one (3), as well as the previously prepared derivatives (4-7) were subjected for antimicrobial and antiquorum-sensing evaluation in comparison to different R. communis extracts. Acetyl ... Read more

Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy

2018-09-24 03:43:58 | Keywords Epoxide hydrolase, Gingerols, LTA(4)H, HCT-116, Zingiber officinale, Aminopeptidase,
Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy
Leukotriene A4 hydrolase (LTA4H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene which may play an important role in chronic inflammation associated carcinogenesis. [6]-gingerol, the major bioactive compound of Zingiber officinale, is a potential inhibitor of LTA4H, a highly expressed enzyme in colorectal carcinoma. Eighteen compounds; seven of natural origin (including [4]-, [6]-, [8]-, and [10]-gingerol), five new ... Read more

Gingerols: New Therapeutics Applications

2018-09-24 03:54:26 | Keywords Gingerols,
Gingerols: New Therapeutics Applications
Emerging New Therapy Against Colorectal Cancer and Human Drug Resistant Breast Cancer are among our continuous efforts and need for developing novel drug-like lead natural compounds. This book presents a remarkable anticancer activity of natural-derived compound as gingerol and its derivatives compared to the standard universal therapeutic regimen. This book describes new and modern applications of gingerols for treatment of ... Read more

Gingerol-derivatives: emerging new therapy against human drug-resistant MCF-7

2018-09-24 04:02:11 | Keywords Gingerol, Allyl 6-gingerol, 5-fluorouracil, Anticancer drug, breast cancer,
Gingerol-derivatives: emerging new therapy against human drug-resistant MCF-7
Cancer chemotherapies have been improved dramatically over the last two decades. In the case of human breast cancer, the combination chemotherapeutic protocol, cyclophosphamide (CPA), doxorubicin (DOX), and 5-fluorouracil (5-FU) (CDF), is often used. Nevertheless, the clinical usefulness of CDF is limited by its remarkably low therapeutic window and frequent eruption of resistance. These limitations prompted our search for a more ... Read more

New Gingerol Derivative and Other Related Compounds from Zingiber officinale

2018-09-24 04:10:58 | Keywords Zingiber officinale rhizomes, Gingerols,
New Gingerol Derivative and Other Related Compounds from Zingiber officinale
In this article we report the isolation, characterization and evaluation of in vitro anti-colon cancer activity of a new gingerol derivative, namely (S,E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradec-8-en-3-one, (N6), and a known sesquiterpene (1,2-Dihydroxybisabola-3,10-diene,N7), isolated from Zingiber officinale rhizomes for the first time, together with other five known compounds; 6-gingerol (N1), 8-gingerol (N2), 10-gingerol (N3), 4-gingerol (N4) and 4`-O-methyl-6-gingerol (N5). The isolated compounds were identified ... Read more

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Taxonomic hierarchy of classification

2018-10-22 10:42:58 | Taxonomy and anatomy for first year general students
Taxonomic hierarchy of classification
Write the taxonomic hierarchy of classification for a selected plant Read more

Taxonomic hierarchy of classification

2018-10-20 11:15:07 | Taxonomy and anatomy for first year clinical students
Taxonomic hierarchy of classification
Write the taxonomic hierarchy of classification for a selected plant Read more

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