Bilastine (BIL) is a new second-generation antihistaminic drug used for the management of urticaria and rhinoconjunctivitis symptoms. Herein, a spectrofluorimetric method for determining BIL is described. The method is very sensitive, simple, quick, and green. The suggested method depended on the measurement of the original fluorescence of BIL in 1.0 M sulfuric acid at an emission wavelength of 385 nm ... Read more

Bilastine (BIL) is a new second-generation antihistaminic drug used for the management of urticaria and rhinoconjunctivitis symptoms. Herein, a spectrofluorimetric method for determining BIL is described. The method is very sensitive, simple, quick, and green. The suggested method depended on the measurement of the original fluorescence of BIL in 1.0 M sulfuric acid at an emission wavelength of 385 nm ... Read more

The present study aims to investigate the possibility of interaction of donepezil (DP) and galantamine (GAL) as acetylcholinestrase inhibitors, on memantine (MT) hydrochloride in rat plasma by HPLC-fluorescence detection. The separation of MT was achieved within 12 min without interference of DP and GAL on the chromatogram.MT levels in rat plasma with a single administration of MT (2.5mg/kg, i.p.) and ... Read more

A sensitive high‐performance liquid chromatographic method with fluorescence detection was developed to determine memantine (MT) in rat plasma. The method consists of pre‐column labeling of MT with 4‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)benzoyl chloride (DIB‐Cl) and a clean‐up step with solid‐phase extraction. A good separation of DIB‐MT was achieved within 12 min on an octadecylsilica (ODS) column (150 × 4.6mm i.d.; 5 μm) with a ... Read more

The simultaneous determination of triamterene (TRM) and losartan (LOS) in their pure forms and in spiked human plasma was successfully achieved using a novel, simple, sensitive, and selective high-performance thin-layer chromatography (HPTLC) method with reflectance/absorbance mode for detection. This method has been validated and established according to International Council for Harmonization (ICH) criteria. Excellent separation of the coadministered drugs was ... Read more