Bilastine (BIL) is a new second-generation antihistaminic drug used for the management of urticaria and rhinoconjunctivitis symptoms. Herein, a spectrofluorimetric method for determining BIL is described. The method is very sensitive, simple, quick, and green. The suggested method depended on the measurement of the original fluorescence of BIL in 1.0 M sulfuric acid at an emission wavelength of 385 nm ... Read more

Bilastine (BIL) is a new second-generation antihistaminic drug used for the management of urticaria and rhinoconjunctivitis symptoms. Herein, a spectrofluorimetric method for determining BIL is described. The method is very sensitive, simple, quick, and green. The suggested method depended on the measurement of the original fluorescence of BIL in 1.0 M sulfuric acid at an emission wavelength of 385 nm ... Read more

The present study aims to investigate the possibility of interaction of donepezil (DP) and galantamine (GAL) as acetylcholinestrase inhibitors, on memantine (MT) hydrochloride in rat plasma by HPLC-fluorescence detection. The separation of MT was achieved within 12 min without interference of DP and GAL on the chromatogram.MT levels in rat plasma with a single administration of MT (2.5mg/kg, i.p.) and ... Read more

A sensitive high‐performance liquid chromatographic method with fluorescence detection was developed to determine memantine (MT) in rat plasma. The method consists of pre‐column labeling of MT with 4‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)benzoyl chloride (DIB‐Cl) and a clean‐up step with solid‐phase extraction. A good separation of DIB‐MT was achieved within 12 min on an octadecylsilica (ODS) column (150 × 4.6mm i.d.; 5 μm) with a ... Read more

People frequently administer Tizanidine (TIZ) to treat spasticity resulting from diseases like multiple sclerosis or spinal cord injuries. It also helps prevent muscle spasms. It helps to relax and release tense and stiff muscles by inhibiting specific nerve signals in the brain and spinal cord. The technique employed in this study made use of the unique ability of benzofurazan to ... Read more

A novel, efficient, and sensitive high-performance thin-layer chromatography (HPTLC) method has been developed and validated for the concurrent measurement of amlodipine besylate (AML besylate) and azilsartan (AZL) in human plasma spiked with the mixture. Reflectance/absorbance densitometry was conducted using toluene‒ethyl acetate‒methanol‒acetone‒ acetic acid (6:1.5:1:0.5:1, V/V) as the mobile phase, and separation was achieved on a precoated silica gel HPTLC plate. ... Read more

The appearance of multidrug-resistant Gram-negative bacterial infections, along with the lack of newly discovered antibiotics, resulted in the return to old antimicrobial medications like Polymyxins. As a result, the suggested technique aims to develop a fast, environmentally friendly, and sensitive fluorimetric method for quantifying Polymyxin B. The investigated approach depends on generating a highly fluorescent derivative by a condensation pathway ... Read more

A novel antipsychotic medication named brexpiprazole (BRX) is currently employed for the treatment of schizophrenia and other psychotic disorders. Because BRX’s molecular structure includes a benzothiophene ring, it natively fluoresces. To detect BRX with precision and speed, a flow injection-fluorometric method, which is both sensitive and selective, is recommended. The fluorescence detection was conducted at 364 nm following excitation at ... Read more

A recently developed antipsychotic drug, lurasidone, was determined using a simple, sensitive, and eco-friendly spectrofluorimetric approach. The suggested approach was based on the quantifiable quenching impact of lurasidone on the inherent fluorescence of erythrosine B in an acidic environment employing a Teorell–Stenhagen buffer (pH 4). Following excitation at 530 nm, the quenching of erythrosine B fluorescence was monitored at 552 ... Read more

A novel, environmentally friendly, and sensitive HPTLC method has been developed and validated for simultaneous quantification of duloxetine (DLX) and tadalafil (TDL) in their pure state, laboratory prepared mixtures, and spiked human plasma. This method is particularly important for patients dealing with depression and sexual issues, as it allows for the measurement of these co-administered antidepressant and sexual stimulant drugs ... Read more