Mohamed Gamal Eldin Hassan Oraby

Lecturer - Assistant Professor, Deartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy

Faculty of Pharmacy

Address: بتي حميل - البلينا - سوهاج


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Electrochemical diagnostics of infectious viral diseases: Trends  and challenges
Infectious diseases caused by viruses can elevate up to undesired pandemic conditions affecting the global population and normal life function. These in turn impact the established world economy, create jobless situations, physical, mental, emotional stress, and challenge the human survival. Therefore, timely detection, treatment, isolation and prevention of spreading the pandemic infectious diseases not beyond the originated town is critical ... Read more

Employ FTIR spectroscopic method for determination of certain multiple sclerosis medications in plasma and pharmaceutical formulations
A selective, simple, rapid, green, cost-effective, and non-destructive assay was proposed for the simultaneous quantitation of Fampridine (FPN), Dexamethasone (DMS), and Fluoxetine (FLX) in spiked human plasma and commercial dosage forms without interference from common drugs excipients. The solid state of a tertiary mixture of FPN, DMS, and FLX was determined by Fourier transformation infrared (FTIR) Spectroscopy. The calibration curves ... Read more

A rapid and sensitive spectrophotometric method has been developed for the quantitative analysis of three antiviral, anti-parkinsonism drugs, namely amantadine (AMA), memantine (MET), and rimantadine (RIM). The method is based on the usage of 1,3-indandione (IDO) as a chromogenic reagent to form charge transfer complexes with the studied drugs and produce colored reaction products with an absorbance maximum at 522 ... Read more

2020 | Keywords terbinafine hydrochloride, res,
Investigating the interaction of terbinafine with xanthenes dye for its feasible determination applying resonance Rayleigh scattering technique.
Terbinafine hydrochloride is a potent antifungal drug indicated for oral and topical treatment of mycoses. A resonance Rayleigh scattering (RRS) method was developed for the determination of terbinafine hydrochloride through a feasible complexation reaction with erythrosine B. In a weakly acidic medium (acetate buffer, pH 5.0), terbinafine hydrochloride can react with erythrosine B through the electrostatic attraction and virtue of ... Read more

A clinical study for the evaluation of pharmacokinetic interaction between daclatasvir and fluoxetine
A simple and sensitive chromatographic method has been developed for the quantitative analysis of an antiviral agent, daclatasvir (DCV), that commonly prescribed for the treatment of hepatitis C viral (HCV) infection. The method was applied to detect DCV in human plasma and real blood samples collected from patients diagnosed with HCV and treated with DCV. The analysis strategy was based ... Read more

One pot synthesis of AuPdPt trimetallic nanohybrid decorated reduced graphene oxide nanosheets for ultrasensing of anti-convulsant drug retigabine (ezogabine)
Herein, a simple reduction method for decoration of reduced graphene oxide (RGO) nanosheets with AuPdPt trimetal nanoparticles was developed. The as-synthesized nanocomposite was characterized detailedly using several techniques such as SEM, TEM, FTIR, CV and EDS. The results showed that the trimetal nanoparticles are well dispersed on RGO nanosheets, preventing the serious aggregation and maintaining good electro-catalytic activity. Benefiting from ... Read more

2013 | Keywords
Interaction study of acetylcholinestrase inhibitors on pharmacokinetics of memantine in rat plasma by HPLC-fluorescence method
The present study aims to investigate the possibility of interaction of donepezil (DP) and galantamine (GAL) as acetylcholinestrase inhibitors, on memantine (MT) hydrochloride in rat plasma by HPLC-fluorescence detection. The separation of MT was achieved within 12 min without interference of DP and GAL on the chromatogram. MT levels in rat plasma with a single administration of MT (2.5 mg/kg, ... Read more

2011 | Keywords
Determination of memantine in rat plasma by HPLC‐fluorescence method and its application to study of the pharmacokinetic interaction between memantine and methazolamide
A sensitive high‐performance liquid chromatographic method with fluorescence detection was developed to determine memantine (MT) in rat plasma. The method consists of pre‐column labeling of MT with 4‐(4,5‐diphenyl‐1H‐imidazol‐ 2‐yl)benzoyl chloride (DIB‐Cl) and a clean‐up step with solid‐phase extraction. A good separation of DIB‐MT was achieved within 12 min on an octadecylsilica (ODS) column (150 × 4.6 mm i.d.; 5 µm) ... Read more

2007 | Keywords
Spectrophotometric determination of certain drugs using Ammonium Cerium (IV) Sulfate and p-Dimethylaminobenzaldehyde
A SPECTROPHOTOMETRIC meth odfor thedetermi na tion of can be measured at 464 nm. The decrease in the absorption intensity at 464 nm caused by the presence of the investigated drugs is directly proportional to their concentration. Investigations were carried out to study all variables and a validation study for the proposed procedure according to USP 2002 was also performed. ... Read more

2005 | Keywords
Oxidized diphenylamine is newly utilized as a redox spectrophotometric reagent for the determination of six pharmaceutically important thiol and thioamide drugs named: acetylcystiene, captopril, carbimazole, propylthiouracil, thiopental sodium, and tiopronin. The method is based on measurement of the decrease in absorption intensify of the oxidized diphenylamine (diphenylbenzidine violet, Lmax= 580 nm) reagent as a result of the reduction effect of ... Read more

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