Abstract Different mechanisms have been suggested for the development of nonsteroidal anti-inflammatory drugs (NSAIDs) induced gastropathy. Angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) have been suggested to have gastroprotective effects, sothe present work aims to elucidate the protective effect of the renin-angiotensin system (RAS) inhibitors through their effect on prostaglandins (PGs) and oxidative stress against peptic ulcer induced ... Read more

Objective: To evaluate the efficacy and the possible mechanism of action of strontium ranelate (SR) in the treatment of knee OA induced by monosodium iodoacetate (MIA) as a new indication of this drug, also, to detect whether cartilage oligomeric matrix protein (COMP) is a reliable biomarker that can facilitate the diagnosis of osteoarthritis (OA). Methods: twenty-four adult male Swiss albino ... Read more

Background: Angiotensin II (ANG II) is a stress hormone and its level dramatically increases in the stomach during stress. In addition, it generates reactive oxygen species (ROS) with cellular damage and inflammation. So the aim of this study is to evaluate the mechanism of losartan and enalapril in the prevention of stress-induced gastric ulcer through their action on mucosal prostaglandin ... Read more

ABSTRACT It is well documented that l-carnitine (L-C) has protective effects against various types of injury. Although its antioxidant action has been reported as a major mechanism, other suggested pathways may be implicated in its protective effect. This study was designed to evaluate the suggested pathways which may be implicated in the protective effect of L-C on liver injury caused ... Read more

Abstract: Synthesis of novel N-acyl hydrazones of nicotinic acid hydrazide via condensation of nicotinic acid hydrazide 3 with the corresponding aldehydes, and to study their hypolipidemic activities. Methods: after design and synthesis of nicotinic acid derivatives, forty-two male adult Wistar albino rats were randomly divided into seven groups; six animals each. Group I, normal control was fed a standard diet. ... Read more