[Background] Cytotoxic T lymphocytes (CTLs) specific to hematopoietic stem cells (HSCs) are thought to play an important role in the development of acquired aplastic anemia (AA). The presence of HLA class I allele-lacking leukocytes as a result of 6pLOH or allelic mutations in about 25% of AA patients strongly suggests that CTLs specific to antigens presented by the specific HLA ... Read more

Leukocytes lacking HLA class I alleles derived from hematopoietic stem/proge nitor cells (HSPCs) that undergo copy number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in patients with aplastic anemia (AA), but the precise mechanisms u nderlying clonal hematopoiesis by such HLA(-) HSPCs remain unknown. To addre ss this ... Read more

Leukocytes lacking HLA class I alleles derived from hematopoietic stem/proge nitor cells (HSPCs) that undergo copy number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in patients with aplastic anemia (AA), but the precise mechanisms u nderlying clonal hematopoiesis by such HLA(-) HSPCs remain unknown. To addre ss this ... Read more

Recent progress in human induced pluripotent stem cells (iPSCs) has opened the door to a better understanding of the biology of human diseases, especially rare disorders such as acquired aplastic anemia, in which the target hematopoietic tissues are depleted. The advent of somatic cell reprogramming has presented new routes for generating hematopoietic stem cells from patient-derived iPSCs and their differentiation ... Read more

The last few decades, an intense interest has been developed in using regulatory T cells (Tregs) for immunotherapy by the biomedical community, depending on the facts that Tregs can modulate both innate and adaptive immunity. Recently, the therapeutic potential of Tregs has been moved to clinical practices in the field of autoimmune diseases and after allogeneic transplantation. Many clinical trials ... Read more

Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide and is etiologically linked to several cancers, including cervical and genital cancers. NKG2D, an activating receptor expressed by NK cells, plays an important role in cancer immune-surveillance. We analyzed the impact of a NKG2D gene variant, rs1049174, on the incidence of HPV-related cancers in Vietnamese patients and utilized various ... Read more

BACKGROUND Nephrotic syndrome is not a disease; it is the manifestation of a wide variety of underlying disease processes. OBJECTIVES The aim of the present study was to investigate different clinic-laboratory and histological patterns of nephrotic syndrome and the relationship between its clinical character and prognosis. METHODS From January 2010 to December 2011 the authors of the present study retrospectively ... Read more

Background: Recent studies have demonstrated that CD36 is involved in the progression of atherosclerosis. Associations between rs1761667 polymorphisms of the CD36 gene and susceptibility to coronary artery disease (CAD) are not obvious. Methods: We studied the relationship between single nucleotide polymorphisms (SNPs), rs1761667 of CD36 gene and the risk of coronary atherosclerosis in a case-control study composed of 71 CAD ... Read more

The human body is colonized by a number of different nonpathogenic microbes that, as a whole, play crucial roles in health and disease. These commensal microorganisms exert profound effects on the development and function of the immune system and therefore strongly influence immune-mediated diseases . Acquired bone marrow (BM) failure syndromes encompass a group of disorders characterized by a reduction ... Read more

It has been unclear the impact of manual thrombus aspiration (TA) on procedural outcomes in patients with ST-elevation myocardial infarction (STEMI) who underwent rescue percutaneous coronary intervention (PCI) after failed fibrinolytic therapy in comparison with primary PCI. Our aim was to test the hypothesis that manual TA may improve myocardial reperfusion and clinical outcomes in patients with STEMI who underwent ... Read more