Amr Othman Abdekareem Mohammad Ahmad

Lecturer - Lecturer

Faculty of medicine

Address: Obstetrics and Gynecology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.


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Immunoreactivity of Kisspeptin and Kisspeptin Receptor in Eutopic and Ectopic Endometrial Tissue of Women With and Without Endometriosis
Endometriosis is characterized by the presence of ectopic endometrial tissues. Mechanisms of tissue dissemination in endometriosis may be similar to those involved in tumor metastasis. We hypothesize that dysregulation of kisspeptin (KISS1), a metastasis suppressor in endometrial carcinoma, may contribute to the pathogenesis of endometriosis. In this study, we characterized the immunoreactivity of kisspeptin and its receptor, KISS1R, in eutopic ... Read more

2019 | Keywords PAI-1, Endometriosis, IHC,
Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis
ABSTRACT PURPOSE Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear. Our objective is to investigate whether plasminogen activator inhibitor-1 expression (PAI-1) in endometriotic tissues is increased in women with DIE. METHODS In this blinded _in vitro_ study, immunohistochemistry and ... Read more

2019 | Keywords RPL, Hypothyroidism, TSH,
Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss
ABSTRACT RESEARCH QUESTION Does initiating levothyroxine treatment based on Thyroid Stimulating Hormone (TSH) > 2.5 mIU/L or thyroid autoimmunity improve pregnancy continuation rates in recurrent pregnancy loss (RPL) patients? DESIGN We conducted a retrospective cohort study of 1064 RPL patients. Subjects were classified as either euthyroid (TSH 0.1 - ≤ 2.5 mIU/L), borderline-subclinical hypothyroid (borderline-SCH, TSH 2.5 – ≤ 4 ... Read more

Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study
_BACKGROUND:_ Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women, yet its clinical presentation shares similarities with several other endocrine disorders such as thyroid disease. Hence, the objective of this study was to further evaluate this association by investigating the clinical, hormonal, and metabolic parameters between subclinical hypothyroidism (SCH) and PCOS. _METHODS:_ This is a cross-sectional ... Read more

2018 | Keywords kisspeptin implantation IVF,
Endometrial leukemia inhibiting factor (LIF) and integrin αvβ3 (ITG αvβ3) expression after kisspeptin trigger of ovulation in mice
OBJECTIVE: Kisspeptin (KISS-1) is a hypothalamic neuropeptide that regulates hypothalamic pituitary ovarian axis function. Pre-ovulatory rise in serum KISS-1 leads to luteinizing hormone (LH) surge that triggers final oocytes maturation and ovulation. Exogenous trigger of ovulation is used in ovarian hyper-stimulation for some infertility cases. KISS-1 and its receptor (KISS-1R) are also expressed in the endometrium. Previous studies in mice ... Read more

Differential expression of Kisspeptin and its receptor in eutopic and ectopic endometrium of women with and without endometriosis
OBJECTIVE: The neuropeptide Kisspeptin regulates gonadotrophin-releasing hormone release from the hypothalamus and is expressed peripherally in the endometrium. It also has anti-metastatic effects in many types of cancer. Like cancer, endometriosis exhibits migration and invasiveness. Our objective was to evaluate the expression of Kisspeptin and its receptor in different endometriotic lesions. DESIGN: This is a case control study. MATERIALS AND ... Read more

Non-visualized pregnancy losses (NVPLS): diagnostic factors and reproductive outcome in a cohort of 1064 patients with recurrent pregnancy loss (RPL)
OBJECTIVE NVPLs is a recognized category in patients with RPL. It is defined as spontaneous pregnancy loss based on decreasing serum or urinary beta-human chorionic gonadotrophin (hCG) in absence of ultrasonographic or histopathologic evidence of pregnancy. The objective of this study is to evaluate the prevalence of couples who experienced only NVPLs in RPL cohort attending tertiary centre and their ... Read more

Oxygen tension influences mouse embryo development when varies in concentration
OBJECTIVE Oxygen inside the female genital tract varies from 2-8% which is the optimum oxygen tension needed for embryo development. The beneficial effects of 5% oxygen tension compared to the atmospheric tension (20%) on embryo development have been reported in animal models. However, the effect of lower or slightly higher oxygen tension on in vitro embryo development is still under ... Read more

Differential expression of Kisspeptin in patients with and without endometriosis
OBJECTIVE Kisspeptin is a neuropeptide that belongs to the Rfamide family. It is known for its crucial role in regulating the onset of puberty. In addition it also regulates sex hormone mediated secretion of gonadotrophins. Recently, expression of Kisspeptin in endometrium was reported. Kisspeptin has also been shown to have antimetastatic properties in different types of cancer. Endometriosis shares many ... Read more

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