Background: Psoriasis is a chronic, immune-mediated skin disease affecting millions, marked by abnormal keratinocyte proliferation. Genetic factors, including the CARD14 gene, epigenetic mechanisms, alongside environmental triggers, drive immune hyperactivation and epidermal barrier dysfunction, influencing disease susceptibility and severity. Objectives: To assess the role of CARD14 gene(rs34367357) polymorphism in Egyptian psoriatic patients. Patients and methods: This cross-sectional study at Qena University ... Read more

Background: Infertility affects 10-15% of couples, with both male and female factors contributing. Non-obstructive azoospermia (NOA) causes 60% of azoospermia cases, and micro-TESE with ICSI is a key treatment. Hormonal stimulation before micro-TESE may improve sperm retrieval, though its effectiveness is debated. Objectives: To compare the efficacy of administering HCG and AEI before performing microscopic testicular sperm extraction Patients and ... Read more

Background Plantar warts represent a therapeutic challenge for dermatologists. Aim and objectives To evaluate the effectiveness of intralesional injection of ionic contra virus therapy (ICVT) (combined digoxin and furosemide) versus intralesional 5-Fluorouracil (5-FU) in the treatment of plantar warts. Patients and methods This study involved 50 patients with plantar warts divided into two equal groups, group I (25 patients) treated ... Read more

Azoospermia can arise from pre-testicular or testicular causes affecting spermatogenesis or from post-testicular obstructions with complete spermatogenesis present in histopathology (Jow et al., 1993). Pre-testicular causes involve defects in the hypothalamus or pituitary gland leading to impaired FSH and/or LH production, resulting in secondary testicular spermatogenic failure. Primary spermatogenic failure, which is not due to hypothalamic-pituitary issues, presents as severe ... Read more

Background: Plantar wart is a common viral infection occurring in the plantar aspect of the foot, caused by human papillomavirus (HPV). Intra‑lesional immunotherapy has emerged as a front‑runner treatment option for plantar warts. Objectives: This study aimed to compare the efficacy and tolerability of intra‑lesional injections of acyclovir versus candida antigen in patients with plantar warts. Methods: This randomised‑controlled clinical ... Read more

Background: Plantar warts are skin lesions on the Plantar surface of the foot resulting from infection of keratinocytes by human papilloma virus. Intralesional bleomycin and 5- fluorouracil (5-FU) are therapeutic options utilized to treat various dermatological conditions including planter warts. Objectives: This study aimed to compare the efficacy and safety of intralesional injection of bleomycin versus 5-FU in patients with ... Read more

Purpose: Non-obstructive azoospermia (NOA) represents the persistent absence of sperm in ejaculate without obstruction, stemming from diverse disease processes. This survey explores global practices in NOA diagnosis, comparing them with guidelines and offering expert recommendations. Materials and Methods: A 56-item questionnaire survey on NOA diagnosis and management was conducted globally from July to September 2022. This paper focuses on part ... Read more

Cutaneous wart is a benign skin growth brought on by the human papillomavirus (HPV), plantar wart is that type of wart occurring in plantar aspect of the foot, To date, over 400 variants of HPV, HPV 2,4,27,57, and 60 are the most common serotypes causing plantar warts. The formation of a successful cell-mediated immune response is necessary for wart regression. ... Read more

Background: Non-obstructive azoospermia (NOA) is a frequent cause of male infertility, and microsurgical testicular sperm extraction (micro-TESE) is an effective technique for sperm retrieval in NOA cases. While the use of hormone stimulation is recommended in cases of secondary hypogonadism, there is still debate surrounding its practice in men with NOA and primary hypogonadism prior to attempting surgical sperm retrieval. ... Read more

Azoospermia can stem from either an obstructive issue or a non-obstructive problem originating in the testes. Distinguishing between these two root causes relies on clinical evaluation of testis size and consistency, hormone testing of FSH levels, and genetic analysis looking at chromosomes, Y chromosome microdeletions, and genes involved in hypogonadotropic hypogonadism. NOA encompasses both primary testicular failure where sperm production ... Read more