Abstract: The effect of aminoguanidine, nicorandil and their combination against oxidative stress in streptozotocin (STZ) - induced diabetes mellitus was assessed in rats by determining changes in blood glucose level, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) in healthy and experimentally induced diabetic rats. Besides, histhopathological examination of kidney and liver tissues was ... إقراء المزيد

ABSTRACT The effect of oleanolic acid or vit E on heavy metal (cadmium) -induced thyroid dysfunction and lipid peroxidation in male rats was studied. MATERIALS AND METHODS:The animals divided into 3 groups each of which 6 rats .The first group were injected with 1mg/kg/day cadmium chloride,1% solution in distilled water subcutaneously daily for 30 days.The second group were injected simultaneously ... إقراء المزيد

BACKGROUND: Phytic acid is an anti-neoplastic agent. We hypothesize that during mammary tumorigenesis, the administration of phytic acid is associated with biochemical changes including enhancement of apoptosis and inhibition of oxidative stress. MATERIALS AND METHODS; An animal model formed of 25 rats was established. The animals were divided into three groups: (1) a control group which received the same phytic ... إقراء المزيد

Cisplatin (cis diammine dichloroplatinum) is a potent antitumor drug. Expansion of the clinical utility of cisplatin has been limited by its toxicity where acute and chronic forms of renal injury have been described due to apoptosis. The mechanism by which it activates the myriad of apoptotic pathways remains unclear. Several studies have now documented the importance of reactive oxygen metabolites ... إقراء المزيد