The aim of this study was to show the efficiency of Goji extract on rat serum globulins which treated with patulin mycotoxin. 50 adult albino male rats were divided into 5 groups. Control group was injected subcutaneously daily with distilled water; groups I and II were injected subcutaneously daily with Patulin (0.2 mg/kg/day) for one and two weeks respectively. Group ... Read more

Pyridopyrimidine derivatives 2, 5 and 7–9 were furnished by the reaction of compound 1 with a variety of reagents, namely, formic acid, acetic anhydride, phenyl isothiocyanate, phenyl isocyanate, carbon disulfide, acetamide and thioacetamide, which in turn were treated with hydrazine to give pyrazolopyridopyrimidine derivatives 4, 6 and 11–13. The potency of the results as antibacterial agents has been evaluated. Most ... Read more

Condensation of 4-phenyl-1H-[1,5]benzodiazepin-2(3H)-one (1) with 3-formylchromone (2) afforded a mixture of 3-(chromenylmethylene)[1,5]benzodiazepinone 3 and 14-chromenylbenzodiazepino[2,3:6,5]pyrano[2,3-b]benzodiazepine 4. Ring rearrangements of compound 3 with different nucleophilic reagents, such as potassium hydroxide and/or ammonium acetate led to rearrangement into pyranobenzodiazepine 5 and pyridobenzodiazepine 6, respectively. Treatment of compound 3 with hydrazine hydrate, hydroxylamine hydrochloride, malononitrile, cyanothioacetamide, 2-cyano-3,3-disufanylacrylonitrile, and/or 2-cyano-3-phenylamino-3-sufanylacrylonitrile, has been carried out ... Read more

Patulin caused severe damage in several organ systems like kidney, intestinal tissue and immune system. The objective of this study is to show the effects of patulin mycotoxin on some biochemical parameters and histological changes on male rats’ kidney. 50 adult albino male rats were divided randomly into 5 groups. Control group was injected subcutaneously daily with distilled water; groups ... Read more

A convenient synthesis of a series of substituted 4'-oxo-3',4'-dihydro-(1'H)-spiro[pyran-4,2'-quinazoline]- 3-carbonitrile and 4'-oxo-3',4'-dihydro-(1'H)-spiro[pyran-4,2'-quinazoline]-3-ethylcarboxylate via the reactions of versatile and readily accessible 3-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)pentane-2,4-dione 1 with the appropriate reagents, is described here. Read more