A novel and selective High Performance Thin Layer Chromatographic (HPTLC) method was developed for the simultaneous determination of triamterene (TRM) and losartan (LOS) in their pure forms and spiked human plasma using fluorescence detection. The challenge of differing optimal pH values for maximum fluorescence in TRM and LOS detection was addressed by devising a strategy for detection in various pH ... Read more

The simultaneous assay of duloxetine hydrochloride (DLX) and avanafil (AVN) in their pure forms, synthetic mixtures, and spiked human plasma was achieved using a novel, eco-friendly, sensitive, and specific HPTLC methodology that have been established and validated. Measuring the levels of co-administered antidepressants and sexual stimulants in biological fluids is an important step for individuals with depression and sexual problems. ... Read more

A novel antipsychotic medication named brexpiprazole (BRX) is currently employed for the treatment of schizophrenia and other psychotic disorders. Because BRX’s molecular structure includes a benzothiophene ring, it natively fluoresces. To detect BRX with precision and speed, a flow injection-fluorometric method, which is both sensitive and selective, is recommended. The fluorescence detection was conducted at 364 nm following excitation at ... Read more

A direct, precise, rapid and simple flow injection approach has been applied to determine vilazodone HCl (VZN) in pharmaceutical dosage forms and biological fluids. VZN has an indole ring as part of its structure, which gives it a significant native fluorescence. The study was based on determining the strong intrinsic fluorescence of VZN, which was measured at 486 nm after ... Read more

This study investigates the fluorescence characteristics of formoterol, emphasizing the influence of various experimental conditions on its emission intensity. The fluorescence intensity of FMT was monitored at 342 nm after being excited at 223 nm. Comprehensive optimization of parameters, including pH, buffer solutions, and diluting solvents, revealed that neutral to basic environments and distilled water maximized the fluorescence intensity. The ... Read more

Vilazodone is a recently approved antidepressant medicine used for treating major depressive disorder. A simple, extremely sensitive, accurate and green spectrofluorimetric method was constructed for its determination through formation of ion-pair complex with erythrosine B. The formation of ion-pair complex lowers the dye’s native fluorescence emission measured at 552 nm (λ ex = 530 nm). In terms of analysis, the ... Read more

The importance of green chemistry has never been greater than it is today. With growing concerns about environmental sustainability, resource depletion, and the impact of chemical processes on human health and the ecosystem, the principles of green chemistry offer a crucial framework for addressing these challenges. This approach encompasses the entire analytical process, from sample preparation to instrumental analysis and ... Read more

Mirabegron (MRB) is a β3-adrenoceptor agonist used for managing overactive bladder syndrome. A cost-effective, environmentally friendly, and highly sensitive spectrofluorimetric method was suggested to serve the purpose of quantifying MRB in its pure state, pharmaceutical tablets, spiked human plasma and urine, and testing content uniformity. In the present study, ninhydrin and phenylacetaldehyde react with the amino group moiety of MRB ... Read more

A simple and sensitive chromatographic method has been developed for the quantitative analysis of an antiviral agent, daclatasvir (DCV), that commonly prescribed for the treatment of hepatitis C viral (HCV)infection. The method was applied to detect DCV in human plasma and real blood samples collected from patients diagnosed with HCV and treated with DCV. The analysis strategy was based on ... Read more

A green-complied spectrofluorimetric approach for quantification of the antidepressant, fluvoxamine, has been established. The method that has been suggested relies on the development of an association complex between fluvoxamine and erythrosine B in an acetate buffer solution. After being excited at 530 nm, the quenching in erythrosine B's native fluorescence caused by complex formation with fluvoxamine was detected at a ... Read more