moh-oraby

Mohamed Gamal Eldin Hassan Oraby

Assistant Professor - Assistant Professor, Deartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy

Faculty of Pharmacy

Address: بتي حميل - البلينا - سوهاج

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Diaryl pyrrolone fluorescent probing strategy for Mirabegron determination through condensation with ninhydrin and phenylacetaldehyde: Application to dosage forms, human urine, and plasma.

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Diaryl pyrrolone fluorescent probing strategy for Mirabegron determination through condensation with ninhydrin and phenylacetaldehyde: Application to dosage forms, human urine, and plasma.
Mirabegron (MRB) is a β3-adrenoceptor agonist used for managing overactive bladder syndrome. A cost-effective, environmentally friendly, and highly sensitive spectrofluorimetric method was suggested to serve the purpose of quantifying MRB in its pure state, pharmaceutical tablets, spiked human plasma and urine, and testing content uniformity. In the present study, ninhydrin and phenylacetaldehyde react with the amino group moiety of MRB ... Read more

A clinical study for the evaluation of pharmacokinetic interaction between daclatasvir and fluoxetine.

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A clinical study for the evaluation of pharmacokinetic interaction between daclatasvir and fluoxetine.
A simple and sensitive chromatographic method has been developed for the quantitative analysis of an antiviral agent, daclatasvir (DCV), that commonly prescribed for the treatment of hepatitis C viral (HCV)infection. The method was applied to detect DCV in human plasma and real blood samples collected from patients diagnosed with HCV and treated with DCV. The analysis strategy was based on ... Read more

A facile on-off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; Application to content uniformity testing.

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A facile on-off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; Application to content uniformity testing.
A green-complied spectrofluorimetric approach for quantification of the antidepressant, fluvoxamine, has been established. The method that has been suggested relies on the development of an association complex between fluvoxamine and erythrosine B in an acetate buffer solution. After being excited at 530 nm, the quenching in erythrosine B's native fluorescence caused by complex formation with fluvoxamine was detected at a ... Read more

Simultaneous determination of triamterene and losartan mixture in spiked human plasma utilizing high‑performance thin‑layer chromatography with ultraviolet detection

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Simultaneous determination of triamterene and losartan mixture in spiked human plasma utilizing high‑performance thin‑layer chromatography with ultraviolet detection
The simultaneous determination of triamterene (TRM) and losartan (LOS) in their pure forms and in spiked human plasma was successfully achieved using a novel, simple, sensitive, and selective high-performance thin-layer chromatography (HPTLC) method with reflectance/absorbance mode for detection. This method has been validated and established according to International Council for Harmonization (ICH) criteria. Excellent separation of the coadministered drugs was ... Read more

Simultaneous measurement of duloxetine hydrochloride and avanafil at dual- wavelength using novel ecologically friendly TLC-densitometric method: application to synthetic mixture and spiked human plasma with evaluation of greenness and blueness.

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Simultaneous measurement of duloxetine hydrochloride and avanafil at dual- wavelength using novel ecologically friendly TLC-densitometric method: application to synthetic mixture and spiked human plasma with evaluation of greenness and blueness.
The simultaneous assay of duloxetine hydrochloride (DLX) and avanafil (AVN) in their pure forms, synthetic mixtures, and spiked human plasma was achieved using a novel, eco-friendly, sensitive, and specific HPTLC methodology that have been established and validated. Measuring the levels of co-administered antidepressants and sexual stimulants in biological fluids is an important step for individuals with depression and sexual problems. ... Read more

Enhancing simultaneous determination of some angiotensin II receptor antagonists and amlodipine in plasma using HPTLC with fluorescence densitometry: Independent fluorescence detection of the co-administrative drugs in the mixture across various pH conditions.

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Enhancing simultaneous determination of some angiotensin II receptor antagonists and amlodipine in plasma using HPTLC with fluorescence densitometry: Independent fluorescence detection of the co-administrative drugs in the mixture across various pH conditions.
A novel and highly sensitive high-performance thin-layer chromatographic (HPTLC) method was developed and validated to quantify a combination of five pharmaceutical mixtures spiked to human plasma. The compounds comprised Amlodipine (AML) along with five angiotensin II receptor antagonist drugs (AIIRAs), namely Olmesartan (OLM), Telmisartan (TLM), Candesartan (CAN), Losartan (LOS), and Irbesartan (IRB). HPTLC was performed on silica gel 60 F254 ... Read more