Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed ... Read more

INTRODUCTION: Angiogenesis is an essential requirement for cholesteatoma growth and expansion. It is mediated via variety of cytokines and growth factors like basic fibroblast growth factor (basic-FGF). Localization of basic FGF in cholesteatoma matrix and its correlation with the destructive capacity of cholesteatoma were seldom seen in previous reports. METHODOLOGY: A prospective immunohistochemical study was employed using 19 acquired cholesteatoma ... Read more

Cholesteatoma is a proliferative disease of the middle ear with bone resorption activity. Its pathogenesis remains controversial and has yet to be clarified. Cytokeratins represent a well-known epithelial proliferative and differentiation markers. In the current study, we investigated expression of a large set of cytokeratins in cholesteatoma matrix versus deep meatal skin tissues from the same patients. Methodology: An immunohistochemical ... Read more