Evidence has been accumulated that some of the angiotensin II type 1 receptor blockers have insulin- sensitizing property. Insulin resistance is the comer stone not only in the development of type 2 diabetes mellitus but also in the development of most of its vascular complications. Insulin resistance is associated with a chronic low grade inflammation. Proinflammatory cytokines are recently reported ... إقراء المزيد

INTRODUCTIONF: as (Apo-I /CD95) is a widely expressed membrane-anchored protein that induces apoptosis. Keratinocytes constitutively express the Fas antigen and Fas- mediated apoptosis may characterize several pathological conditions affecting human skin. Soluble Fas (sFas) has been demonstrated in serum by alternative mRNA splicing of Fas receptor. It can antagonize cell surface Fas function by downregulating Fas- mediated apoptosis and its ... إقراء المزيد