Infectious Bronchitis Virus (IBV) infection poses significant challenges to poultry health and production. This study investigates the modulation of inflammatory cell death pathways in IBV-infected macrophages through inhibiting either caspases or COX-2/PGE2 pathway. We measured intracellular and extracellular viral genome loads, cell viability, apoptosis, and necroptosis after infecting cells with two disparate IBV strains, respiratory Conn A5968 and nephropathogenic DMV/1639. ... Read more

this study, we investigated the localized pathogenesis of infectious bronchitis virus (IBV) in chicken tracheal organ cultures (TOCs), focusing on the role of inducible cyclooxygenase (COX-2). Two divergent IBV strains, respiratory Connecticut (Conn) A5968 and nephropathogenic Delmarva (DMV)/1639, were studied at 6, 12, 24, and 48 hours post-infection (hpi). Various treatments including exogenous prostaglandin (PGE)2, a selective COX-2 antagonist (SC-236), ... Read more