Validating Distinction between Respiratory and Nephropathogenic Infectious Bronchitis Virus Strains via Chicken Tracheal Organ Culture: Insights on Innate Immune Enhancement and the COX-2/PGE2 Pathway
The findings reveal distinct patterns of COX-2 expression, PGE2 production, and immune responses associated with different IBV strains, highlighting the complexity of host-virus interactions. •IBV genome load and protein expression peaked at 12 and 24 hpi, respectively. •Conn A5968-infected TOCs exhibited continuous COX-2 expression for up to 24 hpi, extended PGE2 production up to 48 hpi, and reduced inflammatory cytokine ... Read more