Nucleotide and Phenotypic Analyses of Quasispecies Detected in the Spike 1 Gene and its Encoded Protein following IBV Infection in Laying Hens.
The Spike (S) gene encodes the S envelope glycoprotein and encoded by the amino-terminus S1 gene, and the carboxyl-terminus S2 gene (de Haan et al., 2004). The S1 gene contains 3 hypervariable regions (HVR) crucial for viral infectivity, with high rates of substitution and recombination due to the RNA nature of the virus (Moreno et al., 2017). The “quasispecies” concept, ... Read more