A variety of genetic changes, responsible for the genomic instability of cancer cells, have frequently been found in primary head and neck squamous cell carcinoma (SCC). We studied the frequency of genomic instability in SCC of the pharynx and larynx compared to the degree of tumor differentiation to determine if there is any correlation between. The study group included 30 ... Read more

Background & aims: Genomic instability promotes colon carcinogenesis by inducing genetic mutations, but not all genes affected by this process have been identified. We investigated whether genomic instability in human colorectal cancer (CRC) cells produces mutations in the hepatocyte growth factor (HGF) gene. Methods: We genotyped human colon tumor tissues and adjacent nontumor tissues collected from 78 patients University of ... Read more