Heart failure with preserved ejection fraction (HFpEF) is prevalent and often accompanied by the metabolic syndrome. Current treatment options are limited. Here we test the hypothesis that combined A1/A2B adenosine receptor blockade is beneficial in obese ZSF1 rats, an animal model of HFpEF with the metabolic syndrome. BG9928, a combined A1/A2B receptor antagonist, was administered orally (10 mg/kg/day) to obese ...
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