Many non-Hodgkin's lymphomas (NHLs), reactive processes and some leukemias may contain large transformed lymphocytes that resemble in appearance, and perhaps in immunohistochemical features, Hodgkin Reed Sternberg (HRS) cell or Lymphocyte Predominant cell (LP); the essential landmark for diagnosis of Hodgkin's lymphoma (HL) (Rosai, 2004). Differentiation from mimickers is important because current multimodality treatment protocols achieve cure in over 90% of ... Read more