Immunohistochemical expression of phosphatase and tensin homolog in endometrial hyperplasia and carcinoma
Introduction: The phosphatase and tensin homolog (PTEN) gene is localized on chromosome 10q23. It is a tumor suppressor gene that inhibits cell proliferation by regulating intracellular signaling pathways, and this activity can be abolished by mutations of the PTEN gene. PTEN is frequently mutated in a wide range of human tumors. Aim of the study: In this study, we evaluated ... Read more