Mahmood Ahmed Hamed Ahmed

Lecturer - Lecturer

Faculty of medicine

Address: Otorhinolaryngology Department, Sohag University Hospitals, Sohag, 82524, Egypt



Publications Which contain the keyword: cholesteatoma

Localization of basic fibroblast growth factor in cholesteatoma matrix; an immunochemical study
Abstract: Objectives; to investigate the expression of b-FGF in the matrix of human acquired cholesteatoma compared to the deep meatal skin. To our knowledge, this topic has not been fully investigated before. Materials and methods; an immunochemical study was employed. Cholesteatoma tissues from adult patients were collected during surgery (n=19). Control specimens were taken from the deep meatal skin (n=8) ... Read more

2018-10-22 09:33:52 Keywords temporal bone, middle ear, Congenital, cholesteatoma,
Case report of congenital cholesteatoma in the oval window and posterior mesotympanum surrounding a dehiscent fallopian canal in a young adult
Congenital cholesteatoma is defined as cholesteatoma occurring behind an intact tympanic membrane (TM). In the middle ear, it has different stages according to its site and relation with surrounding structures. We report an unusual case which is congenital cholesteatoma in the oval window and posterior mesotympanum surrounding a dehiscent fallopian canal in a young adult without obvious lesion behind intact ... Read more

2018-10-22 10:21:37 Keywords Bone Resorption, Acquired, cholesteatoma, Pathogenesis,
Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed ... Read more

2018-10-22 19:33:49 Keywords cholesteatoma, middle ear, Cytokeratin 17, Bone Resorption,
Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation with Its Destructive Capacity
OBJECTIVES Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate ... Read more

2018-10-22 19:39:31 Keywords cholesteatoma, Acquired, Basic FGF, middle ear,
Expression of basic Fibroblast Growth Factor in acquired cholesteatoma and correlation with its destructive capacity
INTRODUCTION: Angiogenesis is an essential requirement for cholesteatoma growth and expansion. It is mediated via variety of cytokines and growth factors like basic fibroblast growth factor (basic-FGF). Localization of basic FGF in cholesteatoma matrix and its correlation with the destructive capacity of cholesteatoma were seldom seen in previous reports. METHODOLOGY: A prospective immunohistochemical study was employed using 19 acquired cholesteatoma ... Read more

2018-10-22 19:59:20 Keywords cholesteatoma, Acquired, cytokeratin, Immunohistochemistry,
Cytokeratin expression pattern in acquired cholesteatoma versus meatal skin; an immunochemical study.
Cholesteatoma is a proliferative disease of the middle ear with bone resorption activity. Its pathogenesis remains controversial and has yet to be clarified. Cytokeratins represent a well-known epithelial proliferative and differentiation markers. In the current study, we investigated expression of a large set of cytokeratins in cholesteatoma matrix versus deep meatal skin tissues from the same patients. Methodology: An immunohistochemical ... Read more

2018-10-22 20:09:15 Keywords cholesteatoma, staging, Immunohistochemistry, cancer,
SOM CLEFT Scoring/Staging System for Tympanomastoid Cholesteatoma
_OBJECTIVES_: To adopt a newly designed scoring/staging system for of tympanomastoid cholesteatoma similar to cancer staging protocols. _METHODS_: Our system relied on clinical, CT findings, and confirmed with intraoperative findings. All bony items that could be affected by cholesteatoma were scored, including: scutum (S), ossicles (O), mastoid (M), posterior canal wall (C), lateral sinus plate (L), inner ear (E), facial ... Read more

2018-09-24 06:57:02 Keywords Immune Cells, cholesteatoma,
Immune Cell Profile in Invasive Cholesteatomas: Preliminary Findings
BACKGROUND Cholesteatoma consists of keratinizing squamous epithelium, granulation tissue and keratin plugs. The pathogenesis of cholesteatoma may be related to alterations in the stromal immune cell infiltrate. OBJECTIVE To examine the immunophenotypic characteristics of the immune cell infiltrate in invasive cholesteatomas MATERIALS AND METHODS This study included 12 patients with invasive cholesteatomas causing wide bone erosion of the mastoid, middle ... Read more

2018-09-25 08:14:40 Keywords cholesteatoma, One-stage, Auto,
One stage reconstruction in management of extensive cholesteatoma
One-stage reconstruction utilizing mainly autogenous materials was done to assess feasibility, safety, and functional outcome. The study included 31 patients with extensive cholesteatoma. Wide exposure through canal wall-down (CWD) procedure, eradication of the pathology, and establishment of Eustachian tube patency were the principal goals leaving an area free of residual disease suitable for one-stage reconstruction. Autogenous conchal cartilage was utilized ... Read more

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