bahgat

Bahgat Ramadan Mahmoud Hussein

Lecturer - Lecturer, Chemistry Department, Faculty of Science, Sohag University

Faculty of science

Address: Chemistry Department, Faculty of Science, Sohag University

19

Like

Publications Which contain the keyword: Pyridines


2018-11-14 13:56:59 Keywords Pyridines,
Synthesis, in vitro Antibacterial and in vivo Anti-inflammatory Activity of Some New pyridines
Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group, 1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied. ... Read more

2018-10-31 16:38:24 Keywords thienopyridines, Pyridines, phase transfer catalysis,
Synthesis of Novel Fused Heterocycles Based on 6-Amino-4-phenyl-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile
Under phase transfer catalysis conditions, 6‐amino‐4‐phenyl‐2‐thioxo‐1,2‐dihydropyridine‐3,5‐dicarbonitrile (1) was allowed to react with halo compounds, acrylonitrile, chloroacetyl chloride, ethyl cyanoacetate, formamide, triethylorthoformate, or formic acid to give new derivatives of fused pyridines 2–22, respectively. Acetylation of compound 1 using acetic anhydride afforded product 23, which in turn underwent intramolecular cyclization in pyridine to give the corresponding pyrido[2,3‐_d_]pyrimidine 24. Read more

2018-09-12 21:42:04 Keywords Pyridines, thiophenes, thienop,
SYNTHESIS, IN VITRO ANTIBACTERIAL AND IN VIVO ANTI-INFLAMMATORY ACTIVITY OF  NEW PYRIDINES
Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group, 1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied ... Read more

2018-09-10 12:51:46 Keywords Pyridines,
New Heterocyclic Compounds Derived from 4,6-Diamino-3-cyano-2-methylthio-pyridine and their Biological Activity
Treatment of 4,6-diamino-3-cyano-2-methylthiopyridine (1) with aqueous KOH or hydrazine hydrate afforded the corresponding nicotinamide 2 and pyrazolo[3,4-b]pyridine 3, respectively. Reaction of compound 1 with bromine, sulfuryl chloride, formaldehyde, or aromatic diazonium salts gave 5- bromopyridine 4, 5-chloropyridine 5, dipyridylmethane 6, and azo dyes 7–10, respectively. Compound 1 reacted with diketones to yield the corresponding butenylamino derivative 11 and amides 12–15, ... Read more

Synthesis, in vitro Antibacterial and in vivo Anti-inflammatory Activity of Some New pyridines
Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group,1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied. Read more

2018-09-01 11:24:28 Keywords Pyridines,
Synthesis and Antimicrobial Screening of Fused Heterocyclic Pyridines
In an attempt to find a new class of antimicrobial agents, a series of pyridoxazepine, pyridothiazepine, triazepine, naphthyridine, pyridopyrimidine, and other related products containing pyridine moiety were synthesized _via_ the reaction of 2‐amino‐6‐chloro‐3,5‐dicyanopyridine 1 with nucleophilic chemical reagents. These compounds were screened for cytotoxicity and their antimicrobial activity. Most of products showed inhibitory effect. Read more

  • «
  • 1
  • »