Hyperbaric oxygen therapy (HBOT) is defined as the use of oxygen under pressure to increase oxygen levels in different tissues. Nowadays, HBOT is recommended as single therapy or in combination with other medical treatments like surgery or medicine for specific diseases. HBOT has a number of applications in emergency situations such carbon monoxide poisoning, envenomation from spider and snake bites, compartment syndrome, and central nervous system injury and also has a benefit in many chronic illness states like delayed wound healing. There are only a few publications on how HBOT affects erectile function, but many publications reported about its role in fournier's gangrene, radiation-induced cystitis, and interstitial cystitis that considered the principal indications of HBOT in genitourinary medicine. The rational of HBOT rely on how gases with different solubilities, particularly oxygen, behave in tissues and fluids under different pressures and volumes. Few reports about HBOT and erectile function in literature were found. HBOT is safe when performed following accepted standards except for minimal hazards.