Background: Skin diseases are a major health problem affecting a high proportion of the population and causing distress and disability. Disabled children may be particularly susceptible to skin disorders. Data regarding the dermatological problems encountered among physically and/or mentally challenged children are limited in Egypt. Objectives: The present study aimed to determine the pattern and the prevalence of skin diseases among disabled children attending special schools in Sohag, Governorate Upper Egypt. Patients and methods: This study was a cross-sectional study carried out in September 2013 and April 2014 including students in all schools caring for disabled students in Sohag Governorate. A total of 1107 students (99 blind,740 deaf mute and 268 mentally retarded) aged 6–25 years were subjected to dermatological examination. Results: The mean age of the students was 13.82 ± 3.72 years. The male to female ratio was 1.87: 1. Skin disorders were observed in 756 students, with an overall prevalence of (68. 29%) and 351 (31.71%) were clinically free. Allergic skin diseases, infectious skin diseases, acne vulgaris , pigmentary disorders, ichthyosis, hair disorders, scars and skinxerosis were the most frequent diseases among disabled school children accounting for (63.78%). Conclusion: Allergic skin diseases, infectious skin diseases and acne vulgaris were the most prevalentdermatoses among disabled school children in Sohag Governorate. Eczema was the most prevalent allergic disorder. Pediculosis capitis was the most prevalent infectious disorder.