BACKGROUND:. Scorpions are arthropods belonging to class arachnida. The value of antivenom was never questioned following snake bites, but opinions differ in case of scorpion stings. OBJECTIVES: To investigate the effectiveness of scorpion antivenom in preventing or abolishing the histopathological changes occurring in the parenchymatous organs following experimental scorpion envenoming. METHODS: Forty five male Albino rats were divided into nine groups, five animals each: Group 1 was control; Groups 2, 3, 4 and 5 were subcutaneously injected with the LD50 (35µg) of scorpion venom then sacrificed after 1, 3, 7 and 10 days of injection respectively. Groups 6, 7, 8 and 9 were subcutaneously injected by the LD50 followed by IV injection of scorpion antivenom after 30 min of envenoming, then sacrificed after 1, 3, 7 and 10 days of administration respectively. Kidney, liver, lung and heart were evaluated for the histopathological changes in all examined groups. RESULTS: Groups 2, 3, 4 and 5 showed many histopathological changes in most examined organs. The renal corpuscles and renal tubules suffered from severe cellular degeneration.The liver revealed manifestations of both degeneration and apoptosis.The lungs, showed severe cellular infiltration in the interalveolar septa and congestion of the blood capillaries with extravasation of RBCs. The cardiac muscles showed no apparent morphological changes. All the previous changes were less marked in groups 6, 7, 8 and 9. CONCLUSION: Scorpion antivenom was found to be effective in abolishing some of the various histopathological changes occurring in the parenchymatous organs following scorpion envenoming.