Pyridopyrimidine derivatives 2, 5 and 7, 8, 9 were furnished by the reaction of compound 1 with a variety of reagents, namely, formic acid, acetic anhydride, phenyl isothiocyanate, phenyl isocyanate, carbon disulfide, acetamide and thioacetamide, which in turn were treated with hydrazine to give pyrazolopyridopyrimidine derivatives 4, 6 and 11, 12, 13. The potency of the results as antibacterial agents has been evaluated. Most of the tested products showed a highly inhibition zone against the two bacterial strains. All compounds have been characterized based on their IR, 1H-NMR and Mass spectra.
Synthesis and in vitro Antibacterial Activity of Some Novel Fused Pyridopyrimidine Derivatives | Request PDF. Available from: [accessed Sep 30 2018].