Objective: To investigate the efficacy of escitalopram in treatment of premature ejaculation (PE).

Patients  and  Methods:  patients  with  PE  (n  =  30)  were  randomly divided  into  two  treatment  groups:  a  group  receiving  Escitalopram 10 mg daily for 1 month  (n = 15); and a group receiving placebo for 1 month (n = 15). A modified version of Chinese index of sexual function for PE was used for patient  evaluation at initial visit, at 10 days inter- vals after start of treatment for 1 month,  at 2 months  after stopping treatment.

Results:  the  mean  score  of  intra-vaginal   ejaculation  latency  time (ILET) was significantly higher in escitalopram group as compared  to placebo group after 30 days treatment (5.6 ± 0.7 vs 6.8 ± 0.4, P < 0.03). At 90 days (2 months  after  stopping  treatment), ILET score in the escitalopram  group  was significantly  higher  than  the  placebo  group (6.7 ± 0.8 vs 3.4 ± 0.5, P = 0.01).

Conclusion: Escitalopram is an effective therapeutic option for patient with PE that may help provide long term control  over ejaculation.