For a wide spectrum of pharmacological effects of polyhydroquinolines, this study introduces a developed
safe, simple, higher yields and fast method for the synthesis of some new hexahydroquinoline derivatives
using one-pot three-component cyclocondensation reaction, via the reaction of 1,3-cyclohexanedione with
primary amine and arylidinemalononitrile or salicylaldehyde derivatives. The prepared compounds were
reacted with different reagents asN,N-dimethylformamide dimethylacetal, acetic anhydride, sulphuric acid,
and hydrazine hydrate forming several polycyclic hexahydroquinoline and acridine derivatives. All these
new compounds have been characterized by spectral data and expected to be effective pharmaceutical drugs.